Association of Resistin, Visfatin, and Osteoprotegerin in Diabetes Mellitus

Abstract

The aims of the study to evaluate the association between diabetes mellitus and resistin, visfatin and osteoprotegerin levels and studying the interaction of  resistin, visfatin and osteoprotegerin with duration of diabetes mellitus. This is a case/control study conducted on a total 88 subjects; sixty eight patients (25 male and 43 female) compared to twenty healthy persons (7 males and 13 females). Venous blood collected from the patients attending to Diabetic Center in Merjan Teaching Hospital / Babylon/ Iraq. Serum was prepared from collected blood, and used to investigate resistin, vistatin and osteoprotegerin. The present study findings revealed a significant decrease in resistin, visfatin and osteoprotegerin levels when compared with controls. On other the hand, the study showed  that the visfatin and osteoprotegerin increased in 11-15 years of duration of diagnosis, while there was no relation between resistin and duration of diagnosis.

Keywords: Diabetes Mellitus, resistin, visfatin and osteoprotegerin.