Effects of Camellia sinensis Leaves Extract on Some Biochemical Parameters in Alloxan-Induced Diabetic Rats

Abstract

This study was designed to evaluate the effect of aqueous leaves extract Camellia sinensis on serum glucose levels and liver enzyme markers in alloxan-induced diabetic rats. Diabetes was induced by a single dose of intraperitoneal injection of 150mg/kg bwt of alloxan, and 100, 200 and 400 mg/kg bwt of the extract was administered orally to different groups of diabetic rats for 3 weeks. A significant decrease (p<0.05) in serum glucose, Total bilirubin (TB) and the liver marker enzymes (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and alkaline phosphatase (ALP)) was observed in groups 4 and 5. The hypoglycemic effects as well as its effects on liver enzymes makes it an attractive recipe for the prophylactic treatment of diabetes.

Keywords: Camellia sinensis, diabetes, liver marker enzymes, rats.