In Vivo Histological Evaluation of the Effect of Pomegranate and Aloe Vera and a Combination of Both on Wound Healing of Buccal Mucosa.

Abstract

Background: Wound healing is a complex and dynamic interplay between various cell types, the extra cellular matrix (ECM), cytokines, and growth factors. Researches indicate that pomegranate and their extract may serve as natural alternatives due to their potency against a wide range of bacterial and viral pathogens. Methanol extract of the fruit especially the peel exhibit the broadest antibacterial activity. Studies on Aloe vera have proved the antiseptic, anti inflammatory, antiviral and antifungal properties and the use of this plant is proved beneficial. This plant is proved to be non allergic and very good in building up the immune system. Aim of the study was to evaluate effect of local application of pomegranate, aloe vera & mixture of both on acceleration of healing of oral mucosa. Materials and methods: Sixty adult male Wistar rats weighting an average of (250-300gm) were used in this study. Incisional buccal mucosal wound was induced in each animal and they were be divided into the following groups control (A) and experimental groups (pomegranate B, aloe vera C, pomegranate and aloe vera D). Results: Mean values of epithelial and stromal cells count at healing site increased with time and highly significant difference was recorded among all studied groups in different durations for epithelium, while for stromal cells highly significant difference was obtained at ten days.

Conclusion: The results of present study indicated that healing of buccal mucosa could be accelerated by combined topical application of pomegranate and aloe vera gel

Keywords: Aloe Vera extract, Methanolic extract of pomegranate peel, wound healing