The Ameliorative Effects of Persia americana Pulps Alcoholic Extract on Fertility of Female Rats Treated with Cyclophosphoamide

Abstract

The experiment was designed to study Persea americana extract effect on female rats fertility treated with cyclophosphamide (C.P.). Plant were extracted with 70% ethanol. Rats were distributed into five groups, first group (T1) was control, second group (T2) was treated with C.P. (2mg/kg) and distilled water, third group (T3) was treated with extract (100mg /kg) and  C.P, fourth group (T4) was treated with extract (200 mg/kg) and C.P, fifth group (T5) was treated with extract (300 mg/kg) and C.P. Oral administration of cyclophosphamide (2mg/kg), cyclophosphamide and persea americana extract (100mg/kg), to rats caused prolong the length of hours in proestrus, metaestrus and diestrus phases, in addition to prolong in days of estrous cycle when likened with T1 group, furthermore, to gradual significant reduction in hours of estrus phase as likened T1 group and further groups. The results of length estrous cycle in days and proestrus, metaestrus and diestrus phases in hours of rats in T4 and T5 groups produced a significant reduced when likened with T2 and T3 groups . Furthermore, there was no significant difference among T4 , T5 and T1 groups in all cycles. In addition, the length of estrus phase hours revealed an important surge in T4 and T5 as likened with T2and T3 groups in all cycles. This study established that extracts at doses (200mg/kg and 300mg/kg) have more defense consequence on fertility than dose (100mg/kg) of extract aganist to cyclophosphamide adverse effect .

Keywords: estrous cycle, cyclophosphamide, Persia americana, fertility.