The Protective Role of Dehydroepandrosterone(DHEA) on the Reproductive Function in Adult Male Mice Treated with Nitrofurantoin

Abstract

The aim to investigate the protective role of daily oral administration of the male reproduction system of mice treated with Nitrofurantoin. Forty eight adult albino mice were divided in to four equal groups as(G1)control , (G2) received 2mg/kg B.w of DHEA,(G3)received Nitrofurantoin at 200mg/kg B.w,(G4)received DHEA and Nitrofurantoin. All parameters were estimated after 30 and 60 day of the experiment. The result revealed the significant decrease testicular index, seminiferous tubules diameters, serum Testosterone and DHEAs level, sperm motility, viability and concentration in Nitrofurantoin treated mice with significant increase in sperm abnormality, serum catalase and peroxynitrite concentration. The opposite result were show in DHEA treated mice. Conclusion, DHEA at 2 mg/kg.B.w has a protective role in male reproduction system of Nitrofurantoin treated mice. This is suggested to be due to its potent antioxidative activity which is able to protect against Nitrofurantoin toxicity.

Keywords: Nitrofurantoin, DHEA, male fertility, catalase, peroxynitrite.