Role of Selenium Selenate in Correction the Effects Induced by Gemcitabine in Male Rats

Abstract

The current study was designed to evaluate the efficiency of selenium to limit the harmful effects of gemcitabine . Twenty four rats divided to four groups. The first considered as a control group , The second injected with gemcitabine , Third group drenched with selenium while the fourth group injected with gemcitabine and drenched with selenium .After 9 days blood samples collected and measurements  carried out to determination the levels of T4 , LH , Testosterone, glutathione , malondialdehyde, alanine transaminase , aspartate transaminase , alkaline phosphatase , urea , creatinine and lipid profile . Results showed significant decrease in T4 , LH , Testosterone , GSH and HDL in rats treated with gemcitabine , while selenium administration with gemcitabine caused significant increase in T4 , GSH and HDL compared with group treated with gemcitabine only . On the other hand, gemcitabine caused significant increase in MDA , ALP , ALT , urea , creatinine , LDL , TC and TG , while those parameters decreased significantly in group treated with selenium and gemcitabine . It was concluded that selenium has protective effect against negative effects induced by gemcitabine .

Keywords: selenium, gemcitabine, hormones(T4,LH),biochemical parameters,rats