Assessment of Intracellular and Extracellular Fluids (Icf, Ecf) Compartments with Antimal, Chloroquine, Coartem, Fansidar and Malareich

Abstract

Quantitative assay with spectrophotometer was used in the determination of plasma sodium, potassium and chloride concentration in the administration of antimal, chloroquine, coartem, fansidar and malareich antimalaria drugs. In the antimal group there was no significant difference in the sodium, potassium and chloride concentration in the plasma when compared with control (P>0.05). Also in the chloroquine group, the sodium and chloride concentrations were not significantly different from the control (P>0.05). However, there was low concentration of potassium which was significant when compared with control (P<0.05). In the Fansidar administration there was no significant difference in sodium, potassium and chloride concentration when compared with control, (P>0.05). Also in the malareich group, the sodium and chloride concentrations showed no significant difference with the control (P>0.05). But there was significant difference in potassium concentration when compared with control (P<0.05). The study observed that chloroquine and malareich therapy affect extracellular fluid compartment of the body and induced hypokalaemia which may result in deficit cell membrane potential and the related general body muscle weakness.

Keyword: Hypokalaemia, antimalarials, ICF, ECF.