Cytogenetic Effects of Benzene on Human Blood Cells

Abstract

The study aims to investigate the cytogenetic effect of benzene on human blood cells in vitro using chromosomes abnormalities and mitotic index test. Different concentrations of benzene were added to human blood culture at 24 hour, then cells were arrested at metaphase to detect chromosomes malformations and its proliferation, the result show that benzene causes increased in mitotic index level and different aberrations in chromosomes which increased with benzene concentrations.

Keywords: Benzene, Chromosomes abnormalities, Mitotic index.