Correlation of histological changes with IgG and thyroid hormone concentrations in nodular toxic goiter patient's.

Abstract

Background : Thyroid disease includes many physiological disorders Toxic nodular goiter one of these disease involves an enlarged thyroid gland that reflex rounded growths called nodules. These nodules  is abnormal and produce too much thyroid hormone.

Methods: This study was conducted to determinate the macroscopical and microscopical changes occurring in thyroid gland affected with toxic nodular goiter of both sexes, males and females. A total number of patients was 80 patients. 15 patients out of 80 were affected with nodular toxic goiter (2 male and 13 female).

Results: Macroscopical examination showed the presence of mono and multinodular lesion with hypertrophy of some follicles and atrophy for other. Calcifications, haemorrhage, bundles of fibers were found with the matrix of thyroid tissues. Concerning microscopical examinations, it had been found that appearance of lymphoid nodules, cellular hypertrophy, hyperplasia and increase number of follicles cysts. Measurements of epithelium, colloid and follicles diameter were significantly (P<0.05) taller than healthy tissues. These changes might be attributed to continuous stimulating effects of thyroid which interne increase the activity of gland and tissues hypertrophied.

Conclusion :Presence of various form of toxic goiter nodules correlated with many histological and  hormonal alterations in addition to enhancements of antibody concentration  .

Key words: nodular goiter  ,  hyperplasia , fibrosis .TSH. IgG