Amino Acid Production and Role of Genetic Engineering Approaches to Strain Improvement for Enhanced Production: Review

Abstract

Amino acids, both proteogenic and non-proteogenic amino acids, are produced at industrial scale for diverse applications. The industrial amino acids production methods include extraction, enzymatic, chemical synthesis and microbial fermentation methods. However, microbial fermentation method has been found to be economically feasible and convenient production scheme for production of L-forms of amino acid in natural and safe way. The fermentation method has also been augmented by improvement of producing microbial strains to meet rapidly growing need for amino acids. The advanced high throughput technique in genetic engineering enables development of efficient strains for amino acid overproduction.  With this review the historical development of amino acid production, different amino acid production methods, and strain improvement techniques are well reviewed and the way forward are recommended.

Keywords: Amino acids, fermentation, microorganisms, strain improvement

DOI: 10.7176/JNSR/13-12-04

Publication date:June 30^th 2022