The Effects of Toxocara canis Infection With and Without Red light on the Levels of Melatonin Hormone and Cytokines Peripherial Blood of Albino Rat

Abstract

Present study was carried during period between August 2010 and February 2011 . A total  of 26 stray dogs were examined to detection of T.canis infection in deferent area of Hilla city . Experimental infection performed in albino male rats and subdivided into five groups these were, control negative and positive group, red negative and positive group and positive blindness group. The rat was killed and their serum were evaluated for cytokine (IL-1? and IL-6) and melatonin hormone.

The present study showed the significant differences in melatonin level in types and time of of T.canis infection and red light exposure  and intercept between them (F=12.357, P=0.05, F=4.247,P<0.001). The present study aimed to show the effect of interleukin (hormone like peptide) especially IL-1? and IL-6, the result IL- ? don't showed significant differences between group (time* type) whereas post hoc analysis showed the significantly decreasing in types of groups in IL-1? concentration. This study also showed significant variation for time, type and intercept between them in interleukin-6 level (F=971.98, P<0.001; F=621.33, P=< 0.001 and F=1.33.26, P< 0.001 respectively).