Extended compartmental absorption and transit model

Abstract

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u and Amidon described an extended compartmental absorption and transit (CAT) model to estimate saturable small intestinal absorption. This model simultaneously considers passive absorption, saturable absorption, degradation, and transit kinetics in the human small intestine Cefatrizine. is an Amino ’’?- lactam antibiotics ’’ that is absorbed by a carrier mediated system (through carriers), it means that follows saturated absorption and might be dose dependent absorption and might be dose dependent absorption to some extent. This type of absorption cannot be explained linear absorption model. This model must be mechanistic and quantitative to estimate dose dependent absorption and degradation in vivo.

No saturated absorption occurs in ileum except the first compartment in which transporters continue to decrease from jejunum to ilium. Gastric emptying is considered to be first order, if residence time is 0.25h.