Formulation and characterization of Solid dispersion of Nisoldipine by Solvent Evaporation Method

Abstract

The aim of this study is to improve the solubility of poorly water soluble drug Nisoldipine by formulating the solid dispersion with different water soluble carriers. This will improve the dissolution rate of antihypertensive drug, Nisoldipine. For this purpose, polyvinyl pyrrolidone (PVP) k-25and polyethylene glycol (PEG) 4000 were used as carriers and dispersion was carried out by solvent evaporation technique. Formulations were characterized by particle size analysis, fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), drug content determination and dissolution studies. The particle size was found in range of 43.52 - 45.12 ?m. FTIR studies showed the compatibility between drug and polymers. DSC study indicated that the drug was in amorphous form which results in better dissolution of the drug from the solid dispersion as compared to the pure drug and physical mixture. Dissolution studies indicated better release for solid dispersions and solubility was also increased 15 folds than pure drug. This could provide the formulation technology with a potential of increased bioavailability of poorly water soluble drug by increasing its dissolution rate.

Keywords: Solid Dispersion, nisoldipine, solvent evaporation, PVP k-25, PEG-4000