Investigation Antibiotic Sensitivities Test, And Presence of ESBL, Identification of Escherichia Coli and Klebsiella Pneumoniae Isolated From Urinary System Infections

Abstract

Extended- spectrum β- lactamases (ESBL) is the most important mechanism of resistance to β -lactam antibiotics in Gram -negative bacteria. In this study, It was determined presence of ESBL and antibiotic sensitivities at Escherichia coli and Klebsiella pneumoniae strains obtained to hospital and community sources in a year. Antibiotic sensitivities and ESBL presence of isolates were detected to disc diffusion method and double disc synergy method. Evaluation of zone diameters was made according to Clinical and Laboratory Standards Institute (CLSI) criteria. Various resistance rates against antibiotics was determined in study results. The most effective antibiotics on E. coli isolates are cephalothin (58%), moxalactam (57%) and piperacillin (48%) and the most effective antibiotics on K. pneumoniae isolates are cephalothin (60%), moxalactam (60%), piperacillin (56%), and cefazolin (50%). ESBL was not detected.

E. coli and K. pneumoniae, isolated from urinary tract system, resistance rates should be noticed. In clinical, antibiotic resistance rates should be periodically measured, followed and used for empirical treatment choice.

Keywords: Escherichia coli, ESBL, Klebsiella pneumoniae