Investigation of Association between Hepatitis B Virus Infection and Type 2 Diabetes Mellitus

Abstract

It was aimed to evaluate the relationship between diabetes and hepatitis B in patients with type 2 diabetes. This retrospective study was conducted between January 2012 and December 2017 in Dicle University Hospital. A total of 686 patients (344 male, 342 female) diagnosed with Type 2 Diabetes Mellitus (T2DM) (whose with HbA1c>6.5) were included. Alcohol users, patients who underwent dialysis and with frequent blood transfusions (such as thalassemia major or hemophilia) were excluded from the study. Patients were divided into two groups as those with hepatitis B (HBsAg >1) and those without hepatitis B (HBsAg <1). Age, gender and liver function tests of the patients were evaluated retrospectively and compared between the two groups. Pearson correlation coefficient was calculated between the variables. Student's t test was used to compare the two groups. Chi-square test was used for categorical variables. In the HBsAg positive patient group; the relationship of HbsAg with Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) was significant (p <0.05), also a statistically significant relationship was found between Hba1c elevation with ALT levels and age (p<0.01). No statistically significant difference was found between HBsAg and HbA1c in HB patients group. There was no significant difference in AST and ALT levels between two groups. Conclusion: There was no significant relationship between HB and T2DM in current retrospective study including T2DM patients.

Keywords: Hepatitis B Virus, Type 2 Diabetes Mellitus, Aspartate Aminotransferase, Alanine Aminotransferase

DOI: 10.7176/JSTR/5-10-10