The relationship between H. pylori infection and lung cancer cross sectional study

Abstract

Background: Helicobacter pylori infection is a common disease and leads to many gastrointestinal and respiratory diseases. It is suspected that one of these respiratory diseases is lung cancer.

Methods: sixty patients with lung cancer and one hundred twenty control subjects have been included to this study. All enrolled subjects (lung cancer patients and controls) underwent a15 minute, lateral flow immunoassay for the qualitative detection of IgG antibodies anti-H. Pylori in human serum (CTK Biotech, Inc USA) and a lateral immunochromatographic assay for the qualitative detection of H. Pylori antigen in human fecal specimen (CTK Biotech,Inc USA) , A p value of <0.05 was considered as significant. The statistical data analysis was performed with SPSS 22. .

Results: The H.pylori seropositivity was (41 /60) (68.3) %in patients with lung cancer but only (16/ 120) (13.3) %in controls and this difference in H.pylori seropositivity between cancers and controls was statistically significant P<0.016. The odds ratio for the association of H.pylori and lung cancer was 3.6 (95% CI =1.24 – 4.8), The H.pylori stool antigen was (22/60) (36.7) % in patients with lung cancer but only (14/120) (11.7) %there is statistically significant P<0.001.

Conclusion increase the prevalence of H.pylori seropositivity was (68.3) %in patients with lung cancer more than  in normal controls (13.3) %.