Mixed Ligand Complexes of Cobalt (II) Barbitone in Aqueous Medium and their Biological Activities

Abstract

Complexes of cobalt (II) barbitone and thiocyanate ion mixed ligands have been synthesized and characterized by a direct mixing method on the basis of their solubilities, melting points, elemental analyses as well as the spectroscopic analyses. Biological evaluations of the solid metal complexes and the free ligand were screened against the selected bacteria pathogens viz: Pseudomonas aeruginosa and bacillus subtitis and fungi species which include Sclerotiania trifoliorun, Fusarium oxyporium, Stemania paradoxa and Botrytis cinerea. The results of the metal complexes analyses have revealed that cobalt ions coordinated bidentately with the ligand through the ring carbonyl oxygen and nitrogen atom of the amide group, and also found to be soluble in ethanol and dimethylsulphuroxide and non-electrolytic in nature/character. The biological activities of metal complexes revealed that they were toxic to the selected fungi but not effective as antibacterial agents except in the mixed ligand metal complexes. However, complexes were more potent than the free ligand.

Keywords: Barbitone, mixed ligand, cobalt and biological activities.