SYNTHESIS OF 4-BENZYLIDENE-2-(4-NITRO- PHENYL) - 4H-OXAZOL-5 -ONE DERIVATIVES WITH SUSPECTED BIOLOGICAL ACTIVITY

Abstract

Oxazolones are five membered heterocyclic compounds containing nitrogen and oxygen as heteroatoms.The C-2 and C-4 positions of the oxazolone are crucial for their various biological activities. A series of oxazolone derivatives (1-11) have been synthesized as potential antibacterial and fungal agent. The newly synthesized compounds were evaluated. compounds have been prepared by the condensation of 4-nitrobenzoylglycine or benzoyl glycine  with aromatic aldehydes in the presence of ethanol, acetic anhydride and glacial acetic acid. The newly synthesized compounds were characterized by FTIR, ¹HNMR, C¹³NMR.

Keywords:- Oxazolone, antibacterial and fungal agent, Synthesis.