Synthesis, Characterization and Antibacterial Studies of Some New 1, 4-bis (3-Phenyl-4,5-Dihydroisoxazol-5-yl)Benzene Derivatives

Abstract

Chalcones, analogs of 1,3-diarylprop-2-en-1-one, form a wide class of compounds containing two aromatic rings bound with vinyl ketone fragment. They are useful in synthesis of various heterocyclic compounds.Chalcones of plant origin are known [1]. Chalcones present great interest as compounds exhibiting antimalarial [2], antibacterial [3],  antifibrogenic [4], anticancer [5], antitrichomonal [6], anti-inflammatory [7],  antileishmanial [8], cytotoxic and antitrypanosoma cruzi [9] activities. While the flavonoid compounds are a group of natural products found in fruits, vegetables, nuts, seeds and flowers as well as in teas and are important constituent of human diet.  They have been demonstrated to possess antioxdidant [10], antihypertensive [11], antiallergic [12],  antinocicepative [13], trypsin inhibitors [14], plant growth regulator [15], antibacterial and antifungal [16,17] activities.

In the last few years microwave induced organic reaction enhancement (MORE)  chemistry has gained popularity as a nonconventional technique for rapid organic synthesis [18] and many researchers have described accelerated organic reactions, and a large number of papers has appeared. Proving the synthetic utility of SMORE chemistry in routine organic synthesis [19] . It has been termed as ‘e-chemistry’ because it is easy, effective,  economical and ecofriendly and is belived to be a step toward green chemistry. In view of these observations and in continuation of our work on biologically active chalcones and their heterocycles [20], we have been planned to synthesize the new 1,4-bis(3-phenyl-4,5-dihydroisoxazol-5-yl)benzene derivatives from chalconesand also studied their antibacterial activity against esherishia coli and staphelococcas aureas .