Synthesis, Characterization and Anti-hyperglycemic Activity of some novel Formazans Derivatives

Abstract

In the present investigation, a series of novel formazans 4[a – h]were synthesized by the condensation of Schiff bases2[a-c] and diazonium salt chloride of various substituted aromatic amines 3[a-c] . The intermediate Schiff bases (2a-2h) were itself synthesized by the condensation of different aromatic amines2( thiocarbohydrazide , nicotinic hydrazide , carbohydrazide) with various aromatic aldehydes1.The completion of reactions  was checked by TLC.The structures of the  formazan compoundswere identified by FT- IR ,¹H-NMR , ¹³C- NMR and mass spectral studies. Newly synthesized compound was  screened for their anti- hyperglycemiaactivity.

Keywords:: Formazans, Schiff bases Anti-hyperglycemic