Synthesis and Structure Activity Relationships of Eusiderin A Derivatives as Antifeedant

Abstract

Eusiderin A(1) which isolated from Eusideroxylon zwagery was converted into some derivatives(2- 10)in order to disclose the structure activity relationship as antifeedant. The structures of these compounds were determined based on their spectroscopic data including ¹H NMR, COSY, and NOESY spectra and mass spectra. The antifeedant activity and Brine Shrimp Lethality test  have been evaluated to demonstrate that 2, 3, 6 and 7 increased significantly the antifeedant activity rather than eusiderin A,  while all of the analogs were classified as non toxic.

Keywords: eusiderin A, E. sparsa, antifeedant, brine shrimp lethality test.