Synthesis and Antibacterial Activity of Phenylhydrazone Schiff Base Derivatives and their Copper(II) Complexes

Abstract

Hydrazone derivatives have exhibited several interesting biological properties such as antimicrobial, antiviral, anti-inflammatory, antiplatelet, antimalarial, and anticancer. In present study, hydrazone of phenylhydrazine, 4-methoxybenzaldehyde, 4-nitrobenzaldehyde and their respective benzenesulfanohydrazones (1-3) and Cu(II) complexes (4-5) were synthesized. Synthesized ligands were characterized by IR, ¹H NMR, and ¹³C NMR whereas Cu(II) complexes were characterized by elemental analysis and IR. The IR spectra of ligand and its metal complexes imply that the schiff base ligand behaves as basic bidentate ligand coordination through the azomethine nitrogen atom and nitrogen atom. In-vitro antibacterial test revealed Cu(II) complexes of compound 2 showed better activity (15mm zone of inhibition) against K.pneumoniae compared to the standard ceftriaxone (11 mm zone of inhibition) which might be due to increase in lipophilicity of the compound.

Keywords: antibacterial activity, benzenesulfanohydrazones, complexes, hydrazone