Synthesis, Characterization and Antibacterial Studies of Mono and Binuclear Copper (II) Complexes of 1, 10 Phenantroline using Ethylenediamine as Spacer

Abstract

Copper is a biologically important element, and several enzymes that rely on it to function have been discovered. However, drug-resistant bacteria are a major problem in the medical world, which causes high mortality rates and increases in health care costs, economic losses. The multidirectional effort has been put to overcome the concern as well as discover new drug molecules. In this aspect, the complexation of organic compounds with metal ions increases the therapeutic potency of the organic compounds. Herein, mono [Cu(Phen)₂Cl]Cl.H₂O, and binuclear [Cu₂(en)(Phen)₄]Cl₄ complexes were synthesized and characterized with the help of ICP‑OES, FT‑IR, and UV‑Vis spectroscopic techniques. The synthesized complexes are proposed with square pyramidal geometries. Moreover, the complexes are characterized by molar conductance measurement, melting point measurement, solubility test, and halide test. Based on the in vitro antibacterial testing, both complexes are biologically active in all studied microorganisms, including the most drug-resistant Klebsiella pneumonia, Surprisingly, the complexes are water-soluble, and the solubility of the synthesized complexes could be viewed as a potential therapeutic application following in vivo cytotoxicity studies.

Keywords: 1, 10‑phenanthroline, ethylenediamine, Cu (II) complexes, and antibacterial activities

DOI: 10.7176/CMR/14-4-02

Publication date:October 31^st 2022