Isolation and Characterization of Triterpenes from Petroleum Ether and Ethyl acetate Extracts of  Stem Bark of Parinari curatellifolia Planch Ex. Benth (Chrysobalanaceae)

Halilu, M.E; October, N; Balogun, M; Musa K.Y; Abubakar, M.S

Isolation and Characterization of Triterpenes from Petroleum Ether and Ethyl acetate Extracts of Stem Bark of Parinari curatellifolia Planch Ex. Benth (Chrysobalanaceae)

Halilu, M.E, October, N, Balogun, M, Musa K.Y, Abubakar, M.S

Abstract

Parinari curatellifolia (Chrysobalanaceae) is a plant used in Nigerian folk medicine for cancer treatment. Through series column chromatography, betulin (lup-20(29)-en-3?,28-diol) and betulinic acid (3?-hydroxy-lup-20(29)-en-28-oic acid) have been isolated from petroleum ether and ethyl acetate extracts of the stem bark of Parinari curatellifolia respectively. The compounds were characterized on the basis of 1D-NMR (¹HNMR, ¹³CNMR and DEPT-45, 90 and 135), 2D-NMR (HSQC, HMBC, ¹H-¹H COSY, ¹H-¹H NOESY), MS and IR spectroscopic studies. These two compounds are reported for the first time as constituents in Parinari curatellifolia.

Key words: Parinari curatellifolia, Chrysobalanaceae, Betulin, Betulinic acid and Triterpene

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ISSN (Paper)2224-3224 ISSN (Online)2225-0956

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Chemistry and Materials Research

Isolation and Characterization of Triterpenes from Petroleum Ether and Ethyl acetate Extracts of Stem Bark of Parinari curatellifolia Planch Ex. Benth (Chrysobalanaceae)

Abstract