Densitometric and Viscometric Study of Diclofenac Sodium in Aqueous Solution in Presence and Absence of Additives at Different Temperatures.

Abstract

The measurement of density and viscosity of diclofenac sodium in aqueous solution have been measured and analyzed in presence of additives viz. NaCl, dextrose, KCl, sodium lactate  in a  range of molarity, m= (4 × 10^-3 to 1.99 × 10^-2) mol.L^-1, at T = (298.15 to 313.15)K using a pycknometer and Ubbelohde viscometer. The density results were used to evaluate the apparent molar volumes. Viscosity results were used to calculate Jones-Dole viscosity B-coefficient. The simple physical properties like density and viscosity are used to explain the molecular interaction in aqueous solutions as well as in presence of additives. Drug therapy now forms a major aspect of therapeutics. The drug interact with various ions, molecules, biological membranes present in the biological system is an important phenomenon.

Keywords: Diclofenac sodium, density, viscosity, apparent molar volume, B-coefficient