Synthesis and Characterization of Gelatin-G-Poly (Acryloyl Amide) Proflavine and Controlled Release Study

Abstract

Gelatin-grafted N- proflavine acryl amide was synthesized through two steps; firstly the Gelatin was grafted with acrylic acid free radically using Ammonium per-sulfate at 60?, Then it was modified to its corresponding acyl chloride derivation, second step included the substitution with amino group of proflavine, in this research Gelatin was used as a natural nontoxic,   water soluble polymer as a drug carrier.

The prepared pro drug polymer was characterized by FTIR and ¹H-NMR spectroscopies, Controlled drug release was studied in different pH values at 37?. Many advantages were obtained comparing with other known methods.

Keywords: Gelatin, Acrylic acid, Proflavine and Gelatin,.and pro-drug polymer