Therapeutic Approaches of Some Novel Glyoxaline Derivatives
Abstract
Gloxaline have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Gloxaline is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, Gloxaline compounds have been an interesting source for researchers for more than a century.
The Gloxaline ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. There are several methods used for the synthesis of gloxaline -containing compounds, and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The Gloxaline derivatives possess extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to review the biological activities of gloxaline during the past years.
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ISSN (Paper)2224-7467 ISSN (Online)2225-0913
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