Synthesis, Characterization and Toxicology Studies of the Copper (Ii) Complex of Sodium Barbitone

Abstract

Complexation of sodium barbitone with Cu(II) has been studied. The complex formed was characterized using physical and spectroscopy studies. In the structural characterized complex, Infrared spectra suggest bidentate coordination of the ligand through one carbonyl oxygen, NaO⁺ oxygen and two carbonyl oxygen of acetate. Electronic spectra revealed octahedral geometry of the complex. Toxicology study was carried out by investigating the effect of the ligand and its complex on cardial muscle, kidney, liver and lung of Sprague dawly rats.

Keywords: Sodium barbitone, metal complex, toxicology study, Sprague dawly rats, Cardial muscle