The Effect of human papilomavirus on esophageal cancer: A double blind study in north of Iran

Abstract

The virus HPV is involved in some kinds of cancers and the DNA of this virus has been observed in skin , genitalia and oral tumors. Among them nearly 30-40 kinds are transfered sexually which have the ability to make sexual wart and cervical cancer.  HPV is one of the affective factors in esophageal cancer as well. the aim of this study was to examine the Effect of human papilomavirus  on esophageal cancer in north of Iran. This was a double blinded case control study conducted in north of  Iran. The total of 40 tumor biopsies plus 40 samples of the control groups have been analysed applying primer Gp5⁺ &Gp6⁺ which are capable of detection high risk types. Results of this study indicates that there were no results confirming the affection of HPV in 40 examined patients as the case group comparing with their couples as the control arm. Non existing HPV virus can be referred to different life style for  example different sexual habits ,and the other reason is the aging of affected people. According this fact hat affection to virus HPV, as an environmental factor, is extremely influenced by people life style, and capability of this virus in induction esophageal cancer.

Key word: Human papilomavirus, esophageal cancer, north of Iran.