Expression and Inhibition of Il-23 by Colon Cancer Cells: A Promising Approach in Prevention of Ibd.
Abstract
Inflammatory bowel disease is chronic uncontrolled inflammation characterized by intense mucosal recruitment of activated leukocytes. Here we have developed an in vitro model for IBD using colon cancer cell line HT-29. Colon epithelial cell line HT-29 expressed elevated IL-23 levels when induced with LPS isolated from various bacterial strains. In this in-vitro model of IBD, IL-23 was playing a key role in inflammation cascade. Action of anti-inflammatory drug Sulfasalizine was studied and was found to block the up regulation of IL-23.
Keywords: IBD (Inflammatory Bowel Disease), HT-29, IL-23 (Interleukin-23), Sulfasalizine, LPS (Lipopolysaccharide).
To list your conference here. Please contact the administrator of this platform.
Paper submission email: JBAH@iiste.org
ISSN (Paper)2224-3208 ISSN (Online)2225-093X
Please add our address "contact@iiste.org" into your email contact list.
This journal follows ISO 9001 management standard and licensed under a Creative Commons Attribution 3.0 License.
Copyright © www.iiste.org