Celerity Difference in Incision Wound Healing Between Ethanol Extract of Curcuma (Curcuma Xanthorrhiza Roxb.) and Povidone Iodine in White Mice (Rattus Norvegicus)

Abstract

Wound is losing or breaking part of body tissue. There are so many causes factor of wound condition. The examples are trauma of dull or sharp thing, explosion, chemical substance, temperature, electric shock or animal bites. Response of organism was reached with stabilized physiologic tissue or organ in the skin, rearranging of skin tissue sign by forming of functional epithelial that covered the wound. Some herbal medicine can used on wound healing such as curcuma. The aim of this study is to know the celerity difference in wound healing process in incision wound with ethanol extract of curcuma, povidone iodine as a control group and without treatment in white mice.This study is a true experimental with 15 white mice, age between 3-4 month and weight 150-250 gram. They were randomly assigned into 3 groups, ethanol extract of curcuma group, control group, and without treatment group. Incision wound is made by scalpel, the length was 2 cm and the depth was 2 mm. The macroscopic observation of wound healing is using scoring system to know wound healing process and measured by ruler to know the wound wide. Results were analyzed using nonparametric statistic test Krusskal-Wallis with 95% confidence interval and continued by Man-Whitney test.The study shows that the fastest wound healing process is by ethanol extract of curcuma for 10,60  0,548 days, povidone iodine as a control group for 13,00  0,707 days, and without treatment for 13,80  0,447 days. The result of difference celerity in wound healing process between all variable is 0,003 and Man-Whitney test shows there is significant difference between ethanol extract of curcuma group and control group (p=0,007). From the result above shows that ethanol extract group is faster than povidone iodine as control group and without treatment in wound healing process

Keywords: Incision wound, ethanol extract of Curcuma, wound healing process