The Relationship of Sepsis Occurrence and The Reduction of Platelet Count: A Research in PKU Muhammadiyah Yogyakarta Hospital for The Period of January to December 2010

Abstract

Sepsis is a complication of infection characterized by systemic inflammation, which eventually can cause damage to several organs. One of the systemic inflammatory response of the body is to increase the number of platelets in compensation against vascular leakage caused by the systemic inflammation that can eventually lead to the overall reduction in the number of platelets. The purpose of this study is to determine the relationship between the sepsis occurrence and the reduction of platelet count. The research method used in this study is cross sectional method, data taken for the period of January to December 2010. The study was conducted at PKU Muhammadiyah Hospital in Yogyakarta. The data obtained will be processed using SPSS 16 for windows with Chi-Square method analysis. In addition, this study also uses the value of the ratio of prevalence to statistically determine the relationship between the sepsis occurrence and the reduction of platelet count. The total patients severe infection with and without sepsis are 76 patients which are 38 sepsis patients and 38 non-sepsis patients. From the patients with sepsis, we got 11 people who experienced platelet reduction, while the other 27 patients have normal platelets. Acquired p value 0,02 and prevalence ratio <1 between the sepsis occurrence and the reduction of platelet count with the research power of 95%. The conclusion of the test statistics with Chi-Square and prevalence ratio value indicates that there is a statistically significant relationship between the sepsis occurrence and the reduction of platelet count with the research power of 95%.

Keywords: Sepsis Occurrence, Reduction of platelet count, platelet count