The Difference of Malondialdehyde and Lipid Profile Level Between Pediatric Patients with Epilepsy Who Had Long Term Valproic Acid and Carbamazepine Therapy

Abstract

Epilepsy is one of the most common neurological impairment in the world. Previous study have suggested that long term used of anti epileptic drugs in children might impair lipid metabolism and increase lipid peroxidation. The purpose of this study is to determine the long term impact of antiepileptic drugs (AED) such as valproic acid and carbamazepine, on malondialdehyde (MDA) and lipid profile (total cholesterol, high density lipoprotein, and low density lipoprotein) level of pediatric patients with epilepsy. It is a Cross-sectional study, performed from May to July 2016 in Neurology Pediatric Ward Dr.Hasan Sadikin Hospital Bandung. There were 61 children, aged 2-14 years who fulfilled the inclusion criteria. Blood sample was drawn to measure MDA and lipid profile (total cholesterol, HDL, and LDL) level in each subject. The study showed higher MDA levels in carbamazepine group and had significant difference (p<0.05) based on Mann-Whitney test on both groups. The lipid profiles, whether it were total cholesterol, LDL or HDL level, were also higher in carbamazepine group and showed significant difference of lipid components in both group (p<0.05) based on MANOVA test. As a conclusion, there is a consideration to observe lipid profile (total cholesterol, LDL, and HDL) level in children with epilepsy treated by long term carbamazepine.

Keywords: Epilepsy, children, lipid profile, malondialdehyde, anti-epileptic drug