Four Entities, Three Theories and Four Scenarios Under the Umbrella of the Second Infection for the SARS-COV-2- Virus in Man

Abstract

The four entities that were overlapped in the sense with post recovery second sars-cov-2 infection in man were as; Re-infection ,co-infection, reactivation infection and stealth infections Three theories tempts to explain the case. Together with a trial to delineate in between them. The infection course may be ;Asymptomatic ,mild, and moderate and severe. The tissue tropism of the virus is lung, then to renal and nervous tissues. The virus genome variate in to six molecular genetic clades, two biotypes as Asian and European, and six patho-types. The co-infectents are: Herps ,adeno ,measles viruses ,S. aureus, N. cattrahalis and Klebsiella. The virus immune-dominant epitopes can induce effector B, memory B, effector auto-reacting B, memory auto-reacting T , effector T and memory T and mucosal invariant T cells. The resulting immune responses are humeral, cellular ,mucosal invariant T cell responses in addition to autoantibody responses. The net results of these responses may terminated by by production of specific antibodies and cytokine and may accompanied by humeral and /or cellular enhancement of the disease. The apparent duration of post-infection immunity seems to be short and the protection efficacy still a matter of debate and four post-recovery immunity scenarios were suggested as sterilizing ,functional ,waning ,and lost immunities.

Keywords: Co-Infection ,infection, re-infection ,reactivation infection ,scenarios.

DOI: 10.7176/JHMN/82-01

Publication date: November 30^th 2020