MPO G-463A Gene Polymorphism and Circulating Matrix Metalloproteinase-9, Myeloperoxidase Levels in Coronary Artery Disease Patients

Abstract

Objective: Coronary artery disease(CAD) patients living in Elazığ region is to assess the levels of matrix metalloproteinase-9(MMP-9) and myeloperoxidase(MPO), polymorphisms MPO gene. Research Design and Methods: Eighty-eight patients with angiographically diagnosed coronary artery disease between the ages of 18-80 who applied to Department of Cardiology, Faculty of Medicine, Firat University were enrolled in this study. MPO, MMP-9 levels in plasma samples of individuals were determined by enzyme-linked immuno sorbent assay (ELISA) according to the kit procedure. MPO polymorphism was studied using the PCR-RFLP technique. Results: When plasma MPO and MMP-9 levels were compared in the control and CAD groups; MPO levels were statistically significant (p <0.05). MMP-9 levels were not statistically significant. MPO gene polymorphism was not found statistically significant in CAD. Conclusion: MPO gene polymorphism is thought to be associated with greater population populations in CAD and may be used in the future as a biomarker for plasma MPO enzyme levels in CAD.

Key words: MPO, coronary artery disease, MMP-9

DOI: 10.7176/JHMN/83-02