Relationship of Type II Diabetes Mellitus in Women with Polycystic Ovarian Syndrome: A Systematic Review

Abstract

Objective: The purpose of my study was to determine the relationship of Type 2  diabetes mellitus in women with PCOS. Background: PCOS is a hormonal disorder affecting millions of women around the world. 1 in every 10 women have PCOS but many women go years before receiving the diagnosis. In fact it is estimated that 70% of PCOS cases have a root cause is insulin resistance, A major risk factor for Type 2 diabetes mellitus. More than half of women with PCOS develop type 2 diabetes. PCOS is linked with higher levels of circulating insulin, which is characteristic in type 2 diabetes. IR is the typical condition of subjects with T2D. Women with PCOS share with people with T2D the same impaired glucose pattern consisting of a prevalent disturbance of fasting blood glucose. Higher levels of IR stress the pancreatic beta cell function, resulting in earlier functional depletion of insulin secretion capacity and higher risk of developing T2D. In this Systematic review I wanted to determine the incidence of type 2 diabetes in women with PCOS. According to the studies that I reviewed women with PCOS have a markedly increased risk of developing type 2 diabetes then women without PCOS and there is a higher prevalence of PCOS in those women who have Type 2 diabetes mellitus rather than non-diabetic. Method:An electric database search was performed (google scholar, PubMed and science direct)  without time limit until january 2020. All studies, fully available in English, assessing the incidence Type II Diabetes Mellitus in Women with PCOS.  Study design: Systematic review.  Results:I reviewed 22 articles and found that there were high risk of Diabetes Mellitus Type 2 in PCOS females then other one. Middle aged women with PCOS were having elevated risk of Type 2 Diabetes Mellitus, So therefore it propped up the needs of PCOS for routine screening of diabetes. The information or data from articles likewise gave furthur clinical bits of knowledge on the side of focusing on BMI (Body Mass Index), glucose (fasting glucose and after glucose ingestion) and in risk stratification and intervention for glucose homeostasis maintenance.

Keywords: Polycystic Ovarian Disease, Type II Diabetes Mellitus, Insulin Resistance

DOI: 10.7176/JHMN/90-13

Publication date:June 30^th 2021