Amoxyclav Resistance Pattern and Aerobic Bacterial Profile in Diabetic Foot Infection Patients in Bangladesh

Abstract

Introduction: The goal of this study was to determine the frequency of bacterial isolates cultured from diabetic foot infections and to assess their amoxyclav resistance and susceptibility.Methods: A total of 378 diabetic foot lesions were included in this prospective analysis. The antibiotic susceptibility pattern of bacteria isolated from foot lesions was assessed using the Kirby-Bauer disk diffusion method.Results: The most commonly isolated Gram-positive bacteria were Staphylococcus aureus, followed by Enterococcus spp. and CoNS. The most commonly isolated Gram-negative bacteria were Klebsiella spp., Pseudomonas spp., Proteus spp., Escherichia coli, Enterobacter spp., Citrobacter spp., Citrobacter freundii, and Proteus vulgaris. Amoxyclav was found to be 100.00% resistant against Pseudomonas aeruginosa and followed by Enterococcus spp. (89.50%), Proteus spp. (87.50%), Staphylococcus aureus (84.30%), Escherichia coli (81.50%), Klebsiella spp. (70.50%) and Enterobacter spp. (69.20%).Conclusion: The present study confirmed the prevalence of amoxyclav drug resistant pathogens (84.90%) in diabetic foot ulcers. The diverse bacteria infecting the wound must be evaluated, as well as the antibiotic susceptibility patterns of the isolates from the infected lesion. This information is critical for selecting the right medications, eliminating resistance trends, and lowering healthcare costs.

Keywords: Diabetic Foot Infection, Polymicrobial Infections, Amoxyclav

DOI: 10.7176/JHMN/94-03

Publication date:October 31^st 2021