QUANTITATIVE DETERMINATION OF HYOSCINE BUTYLBROMIDE (TABLET) IN COMMERCIAL DOSAGE FORM MARKETED AN USED IN MAIDUGURI METROPOLIS, NIGERIA

Abstract

The experiment involves analysis of nine brands of hyoscine butylbromide using ultra violet spectrophotometer in the range of (200-400nm) and high performance liquid chromatography (HPLC) in which the samples were dissolved in various solvents and their various absorbance, peak area at various wavelength were determined and compared with that of the standard, wavelength of maximum absorbance at 210nm for hyoscine butylbromide.

Percentage and milligramme content for each sample was determined so as to note if it was within the acceptable range of (92.5-107.5%) for hyoscine butylbromide. For those that passed the test or if it was below or above the range for samples that are substandard or highly concentrated.

The samples absorbance and peak area was used along side with the standard absorbance and peak area to calculate the percentage content of each sample.

It was observed that of the

Of the nine samples of hyoscine butylbromide tablet, only shreecopan with 93.6% passed using UV spectrophotometer while bixkopan with 99.8%, buscomac 101.6%, spanil 97.2% and unipan 104.7% passed using HPLC.

KEYWORDS: Hyoscine Butylbromide, UV, HPLC