Vitamin B12 and Depression

Abstract

In previous studies a potential connection between cyanocobalamin (vitamin B12) deficiency and depression has been suggested. Currently in the United States, an acceptable serum B12 reference range is 200-900 pg/mL. However, it is suspected that even serum levels within the lower end of this range can result in symptoms consistent with deficiency, including depression. Thus, supplementation of vitamin B12 may be helpful for the treatment in depressed patients.

Keywords: Cyanocobalamine, vitamin B12, depression, Supplementation