The Relationship between Glomerular Filtration Rate and Mean Platelet Volume in Chronic Kidney Disease Patients without Dialysis

Abstract

Various indicators are used to evaluate renal function in chronic kidney disease (CKD) patients such as urea, creatinine, serum cystatin C, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin. However, new clinical parameters are needed to track disease progression. Our goal is to evaluate the relationship between glomerular filtration rate (GFR) and mean platelet volume (MPV) levels in patients with different stages of CKD who are undergoing renal replacement therapy. Two hundred non-dialysis CKD patients with stage 3 (n=84), stage 4 (n=52), and stage 5 (n=64) were included in the study. They were 18–87 years old. All of CKD patients including stage 5 have not received renal replacement therapy during two years. MPV levels were determined by used the electrical impedance technology in Application and Research Hospital of University. Systolic and diastolic blood pressure were measured according to Report of Turkish Society of Cardiology-National Guideline for Hypertension Treatment and Follow Up. SPSS for Windows was used for statistical analysis of the data. For stages 3, 4 and 5 in CKD patients, baseline MPV levels were 7.66±1.04, 8.07±1.16, and 8.88±1.05 fL, respectively; six-month MPV levels were 8.45±1.01, 8.76±0.92, and 9.32±1.08 fL, respectively. The results were statistically significant (p˂0.01). There were significant negative correlations between MPV with GFR in all CKD patients (r=-0.413 for baseline, r = -0.334 for six-month levels). MPV and GFR levels in patients with atherosclerotic cardiovascular disease (ACVD) and diabetes mellitus (DM) were significantly higher than those without ACVD and DM (p˂0.05 for MPV and p˃0.05 for GFR). Monitoring MPV levels in CKD patients may be a useful indicator for tracking renal function and cardiovascular disease risk.

Keywords: Chronic Kidney Disease, Glomerular Filtration Rate, Mean Platelet Volume

DOI: 10.7176/JSTR/5-3-08