Bioadhesive Buccal Tablets of Aminophylline by Direct Compression Method

Chaudhari Rupesh, Patel Ronak, Akarte Anup, Baviskar Dheeraj, Jain Dinesh


Buccal administration of drugs which exhibit a low oral bioavailability is a useful method to achieve higher bioavailability. The objective of present research work is to design and evaluate the prolong release bioadhesive buccal tablet of Aminophylline with goal to increase the bioavalability, reduce dosing frequency and improve patient compliance. Aminophylline is ethylenediamine salt of theophylline. Buccal tablets of aminophylline were prepared by direct compression using different  bioadhesive polymers such as HPMC K4M and Carbopol 934-P. The prepared tablets were subjected to post friability, Hardness thickness, weight variation, drug content and swelling index, bioadhesive strength, In-vitro drug release.

Keywords: Aminophylline, HPMC, direct compression method, Swelling index, in-vitro drug release.

Full Text: PDF
Download the IISTE publication guideline!

To list your conference here. Please contact the administrator of this platform.

Paper submission email:

ISSN (Paper)2224-6088 ISSN (Online)2225-0557

Please add our address "" into your email contact list.

This journal follows ISO 9001 management standard and licensed under a Creative Commons Attribution 3.0 License.

Copyright ©