Chemical Analysis and Short-term Toxicological Evaluation of Garcinia mangostana Seed Residue in Albino Rats

Abstract

The short-term toxicological evaluation of defatted Garcinia mangostana seed residue in rat feed has been investigated in order to determine its suitability as an additive in feed supplement. Proximate analysis of the G. mangostana seed residue (GMSR) showed that it had a high carbohydrate and low protein values: 71.02±0.79 % and 8.09±0.21 % respectively. In vivo experiment with albino rats fed with feed that had its wheat constituent totally replaced by GMSR lasted for six weeks. The albino rats appeared to suffer no toxicological effect and weekly monitoring of the rats showed good physical appearance. The rats in the test group displayed fairly similar body weight gain when compared with those from the control group. There was no significant difference between the haematological and histopathological results obtained for both the experimental and control groups. GMSR seemed to be a good replacement for wheat in rat feed.

Key words: Diet, Garcinia mangostana, proximate composition, total replacement, wheat.