The Effects of Methionine on Paracetamol Induce Live Injury –Hepatomegaly- (Animal Study)

Abstract

This study which was done for a total (45) mice, over a time of 30 days, reflects that paracetamol overdoses causing hepatic enlargement with high significant results (P<0.0001), although combined together with Methionine and by the same intra-gastric route of administration, with no any hepatoprotective effectiveness of Methionine, that there is no significant results (P=0.1566).Also this study reflects; that there were no any effect of Methionine on the ratio of the liver wt. / body wt. of the mice, in which the (P=0.1668 "no significant results), against paracetamol over-doses induce hepatomegaly, while paracetamol was highly significant (P=0.0001) on this ratio, when compared with control group.

Key words: Paracetamol, Methionine, Over-dose, Hepatomegaly (enlargement of the liver).